The fact that KDM4A has known interactions with medications that are used to treat other psychiatric conditions, such as depression, or target dopaminergic or serotonergic systems, as well as drugs used in opioid anesthetics, suggests that KDM4 demethylases may be implicated in relevant biology for opioid behaviors and could represent promising druggable targets [53]. This evidence concerns the gene MBD2 and major depressive disorder.