Furthermore, despite overall levels lower of CD68 expression, the low levels of CD8 expression also seen in DDIR-negative tumours resulted in higher CD68/CD8 gene expression ratios, implying these tumours had a higher proportion of “M2” polarised macrophages (which have been associated with an immunosuppressive tumour microenvironment (TME) [25], compared to DDIR-positive tumours (Fig. 3a). The gene discussed is CD8A; the disease is neoplasm.