In addition, we found high enrichment of H3K4me3 and H3K27Ac modifications at the promoters of β-catenin, miR-17 and HOXA11-AS (Supplementary Fig. 8c–e), indicating that, in addition to promoting β-catenin expression, TCF3-transactivated WDR5 may promote the expression of HOXA11-AS and miR-17 in GC cells. The gene discussed is TCF3; the disease is gastric cancer.