Recently, Sun and Liu et al. reported that HOXA11-AS functions as a scaffold that could bind several RNA-binding proteins (WDR5, PRC2, LSD1, and DNMT1) and inhibit PRSS8 and KLF2 at the transcriptional level, thereby further stimulating β‐catenin protein and promoting GC progression32,33. This evidence concerns the gene KLF2 and gastric cancer.