In the prostate adenocarcinoma dataset (Fig. 3e) two main clusters were identified, one enriched for samples harboring mutations in SPOP or FOXA1 (SPOP | FOXA1mut) (hyper-geometric test p-value < 2.2e-16, recall = 100%) and one enriched for samples characterized by the fusion transcript TMPRSS2-ERG (ERG+) (p-value < 2.2e-16, recall = 96%). This evidence concerns the gene SPOP and prostate adenocarcinoma.