Several investigations demonstrated that expression of MAPK6 mRNA is down-regulated in brain tumors, ovarian carcinoma and cutaneous melanoma, and up-regulated in leukemias, adrenocortical carcinoma, squamous cell lung carcinoma, salivary adenoid cystic carcinoma, tongue squamous cell carcinoma and cervical cancer54. The gene discussed is MAPK6; the disease is cutaneous melanoma.