Based on a recent publication45 reporting that the pathogenetic basis of acne is the alteration in sebocyte differentiation, the less differentiated and with that the more proliferating the sebocytes are the more they are responding to regulatory stimuli, therefore our results point on the therapeutic relevance which the modulation of miR-146a, and with that GNG7 levels, may deliver to acne therapy by targeting inflammation, sebocyte hyperproliferation and sebum secretion at the same time. Here, GNG7 is linked to acne.