Genes belonging to this cluster such as EME1 (Essential meiotic endonuclease 1), FANCI (Fanconi Anemia Complementation Group I) and RAD54L (DNA Repair and Recombination Protein RAD54-Like) are associated with functions related to repairing DNA damage, maintaining genomic stability and mitotic and homologous recombination. Here, EME1 is linked to Fanconi anemia.