However, in the TCGA data set (Table 2), VISTA mRNA expression was significantly associated with glioma grades (p < 0.0001), histological type (p < 0.0001), and molecular subtype (p = 0.0002), but not with otherparameters such as gender (p = 0.647), age (p = 0.4028), Karnofsky score (p = 0.055) and IDH mutation status (p = 0.0702). Here, VSIR is linked to central nervous system cancer.