Parallelly, DKO in MycOE mice also displayed suppression of liver cancer development compared to littermate control mice (Fig. 6a, b).Trmt6/Trmt61a DKO reduced levels of m1A, Pparδ, and Hmgcs2 in MycOE or DEN induced liver tumor tissues (Fig. 6c). This evidence concerns the gene TRMT6 and liver cancer.