TGFB1 and idiopathic pulmonary fibrosis: Of particular note, blockage of TGF-β signaling resulted in attenuation of fibrotic responses during wound healing in bleomycin-induced pulmonary fibrosis (Degryse et al, 2011), informing the current first-line treatment of IPF with pirfenidone and nintedanib (King et al, 2014; Flaherty et al, 2019).