Of 1,546,101 patients with diabetes, 799,529 experienced one of the three definitions of progression: (i) 449,685 patients with new insulin treatment (438,816 male; 10,869 female); (ii) 414,460 with new combination oral hypoglycemic treatment (404,858 male; 9,602 female); (iii) 593,401 patients with ≥1% increase in HbA1c, with the recent HbA1c ≥8% (579,384 male; 14,017 female). The gene discussed is INS; the disease is diabetes mellitus.