Furthermore, FoxO1 is activated in skeletal muscle following strong stress conditions such as starvation, streptozotocin-induced diabetes, or exercise, where it induces the expression of pyruvate dehydrogenase kinase 4 (PDK4) to conserve glucose and gluconeogenesis substrate and decrease the glycolytic flux during energy deprivation [39–41]. This evidence concerns the gene FOXO1 and diabetes mellitus.