SQSTM1 (p62), a cargo protein which binds to autophagy substrates and is degraded with them [49, 59] colocalizes with tau and α-synuclein aggregates in the brain of patients with various neurodegenerative diseases including AD, PSP, Lewy body disease and multiple system atrophy [69]. This evidence concerns the gene SQSTM1 and multiple system atrophy.