This diverse group of diseases includes Alzheimer’s disease (AD), frontotemporal lobe dementia (FTD), progressive supranuclear palsy (PSP), argyrophilic grain disease (AGD) and Pick’s disease (PiD), which vary in terms of the brain regions and cell type affected as well as the precise species of tau that accumulates [37]. The gene discussed is MAPT; the disease is Alzheimer disease.