We show that in EC-Tau mice, p62 accumulation is a very early event in the pathological process, and it occurs before the appearance of somatodendritic MC1 positive tau and well before inflammation (Cd68) or neurodegeneration (loss of NeuN) – a sequence of events also seen in AD patients [20, 59, 65, 70]. The gene discussed is MAPT; the disease is Alzheimer disease.