Previous studies [20–22] have shown that EA2 usually happens as a result of non-sense mutations or deletions and loss of function, FHM and infantile epilepsy with myoclonus happen probably as a result of missense mutations and loss of function in P/Q type calcium channel activity, and DEE happens as a result of both gain of function and loss of function. Here, CACNA1A is linked to infantile epilepsy syndrome.