A previous study showed that knocking out GABRG2 (Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2) leads to a decrease in the expression of CACNA1A, which promotes Generalized epilepsy with febrile seizures plus (GEFS+) disease and increases temperature leading to gradual decrease in CACNA1A expression and contributes to epileptogenesis [24, 25]. Here, CACNA1A is linked to generalized epilepsy.