NFKB1 and non-small cell lung carcinoma: Additionally, in non-small-cell lung cancer (NSCLC), pem was shown to activate the NF-κB signaling pathway, via a ROS- mediated IkBα degradation [56] and it was also shown to increase NFkB-p65 phosphorylation (Ser468) in MSTO-211H cells [57].