The influences of Ang II and candesartan on the motility of HepG2 and HCCLM3 cells transfected with PLC-β1 siRNA were further analyzed by Transwell assay, and the results confirmed that the regulation of Ang II and candesartan on migration and invasion activity in HCC cells with low expressions of PLC-β1 and CaM was significantly weakened (Fig. 8C, D). This evidence concerns the gene PLCB1 and hepatocellular carcinoma.