ACE and hepatocellular carcinoma: In contrast, various microRNAs such as miR-345, miR-219 and miR-126 are now gaining attention as important suppressors of HCC [45–47], and ACE2/Ang-(1–7)/MasR axis may exert a protective effect on the liver by counteracting the over-activated ACE/Ang II/AT1R signaling [48].