The results of this study suggest that the AT1R-mediated PLC-β1/CaM pathway can obviously promote the migration and invasion activity of HCC cells, and the effect of its regulation of pro-angiogenic factors such as VEGF, PDGF and EGFR on HCC angiogenesis will be the next research focus of our team. The gene discussed is PLCB1; the disease is hepatocellular carcinoma.