HOXB3 and acute myeloid leukemia: Many probe sets that were identified interrogate genes that have already been associated with AML, including CEBPD, PBX3, DUSP6, LILR2, HGF, FSCN1, TNFSF10, RUNX1T1, HOXB3, TAL1, SLC40A1, and CLEC11A. CEBPD is thought to be a tumor suppressor gene, given it is commonly hypermethylated in AML and thus results in low CEBPD expression [22].