in 2015 [15], extra pancreatic necrosis volume (EPNV) was found to be significantly associated with the length of the hospital stay, infection, need for surgery or percutaneous intervention, occurrence of organ failure, and death in patients with AP (p < .001 for all); and a cut-off of 100.00 mL of EPNV provided more notable information than that of the current Balthazar score, CTSI and CRP level for predicting the occurrence of infection and organ failure (p < .001 for all). The gene discussed is CRP; the disease is infection.