Given that the enzymatic activity of ABHD12 controls physiological concentrations of the signalling lipids that are associated with the process of phagocytosis (Shanbhag et al., 2020), we wanted to assess if the loss of this lipase activity has any effect on phagocytosis and if this has any implications on our understanding of the pathology of the human neurological disorder PHARC (Fiskerstrand et al., 2010). This evidence concerns the gene ABHD12 and nervous system disorder.