Nearest neighbour analysis demonstrated that the median distance from the CD14+ HLA-DR− cells to CD3+ cells at the invasive margin was either much less (Samples 1,3,4 and 5) or the same (Sample 2) as the distances from the CD14+ HLA-DR − cells to the CD3+ cells in the centre of the tumour. The gene discussed is CD14; the disease is neoplasm.