HP and parasitic infectious disease: Considering only P. vivax-infected participants, all the statistically significant correlations between aging and MDP score values were negative, meaning that increases in age were directly related to a reduction in the global inflammatory disturbance (ssMDP), and in the individual degree of perturbation of fibrinogen, ALT, AST, TNF-α, IFN-γ, haptoglobin and also parasitemia (Fig 5A).