Our observations reported here suggest that older individuals who lived for long time in malaria-endemic area and had been exposed to several Plasmodium infections in the past tend to tolerate the current P. vivax infection through a decrease in perturbation of all pro-inflammatory and tissue damage markers, and increase in MDP levels of IL-10, which may limit tissue damage and minimize sickness [35,51,52]. The gene discussed is IL10; the disease is malaria.