This study of patients hospitalized within 24 hours with community-acquired infection and sepsis at a referral hospital in northeast of Thailand demonstrates that a combination of the CPS-LFI and Hcp1-ELISA or CPS-LFI and OPS-ELISA increased the sensitivity of melioidosis diagnosis over any of the three tests alone while maintaining high specificity. The gene discussed is CAD; the disease is Sepsis.