Type 1 hub genes which tend to get new PPIs in cancer network were enriched in a lot of famous oncogenic signaling pathways [29], including: MAPK signaling pathway (P-value = 1.11x10-27), PI3K-Akt signaling pathway (P-value = 2.27x10-17) and Wnt signaling pathway (P-value = 2.43x10-18) (S5A Fig). This evidence concerns the gene AKT1 and cancer.