Tregs in CML BM were activated, thymic-derived, and overexpressed receptors such as Ctla-4, Gitr, Garp, and Tgf-β1 on the surface that have been previously reported to mediate their activity and immunosuppressive function in various cancer entities (50). The gene discussed is TGFB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.