FACS analysis of the BM from a limited number of newly diagnosed CML patients revealed that a significant fraction of CD4+CD127loCD25+ BM Tregs express the TNFRSF4 on the surface, whereas TNFRSF4 was absent on CD8+ CTLs and CML stem/progenitor cells (Figure 8N and Supplemental Figure 5G). Here, CD4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.