Importantly, the clonogenic potential of normal lin–c-kit+sca-1+ (LSK) hematopoietic stem/progenitor cells (LSKs) derived the BM of naive BL/6 mice was not affected by coincubation of LSKs with CD8+ CTLs from CML mice (Supplemental Figure 3D). This evidence concerns the gene KIT and chronic myelogenous leukemia, BCR-ABL1 positive.