Even though H2–/– and BL/6 LSCs did not differ in their potential to form colonies in primary and secondary replating experiments in vitro (Supplemental Figure 4C), leukemia developed significantly slower in H2–/– CML mice compared with BL/6 CML mice, as indicated by considerably lower levels of L-Gr-1+ cells in peripheral blood (Figure 6A). Here, FSHR is linked to leukemia.