However, the apoptosis rate was similar in Tregs and CD4+ conventional T cells (Tconv) (annexin V+ cells; Tregs CML, 23.87 ± 3.67; Tconv CML, 22.81 ± 7.45) and, thus, cannot explain the increased frequency of Tregs in total CD4+ T cells (Figure 1, G and H). This evidence concerns the gene ANXA5 and chronic myelogenous leukemia, BCR-ABL1 positive.