In this study, we plan to address: (a) whether miR-30e expression is associated with EC incidence; (b) what direct target of miR-30e is involved in EC; (c) what roles miR-30e and its target have in cancer cell proliferation and tumor growth; and (d) whether miR-30e/RPS6KB1 axis is associated with overall survival rate in EC cancer patients. This evidence concerns the gene RPS6KB1 and cancer.