Several recent studies have identified genes that control PD-L1 expression in cancer cell lines (Garcia-Diaz et al., 2017; Gong et al., 2019; Mahoney et al., 2019; Kataoka et al., 2016; Burr et al., 2017; Coelho et al., 2017; Manguso et al., 2017; Mezzadra et al., 2017; Hassounah et al., 2019), and we validated the PD-L1-associated clusters using these candidates. This evidence concerns the gene CD274 and cancer.