HNRNPU and disease arising from reactivation of latent virus: Consistent with the observations from overexpression with exogenous LANA, the results showed that both the expression and nuclear location of HNRNPU are enhanced by KSHV latent infection in iSLK.219 cells under normoxia conditions, and the nuclear localization of HNRNPU is further induced by hypoxic stress (Fig. 6B).