To further determine the role of HNRNPU in KSHV latently infected cells and in response to hypoxia, we performed immunofluorescence assays to examine the localization of HNRNPU in the iSLK cell line and its derived iSLK.219 cells with KSHV latent infection under normoxia or hypoxia conditions. The gene discussed is HNRNPU; the disease is disease arising from reactivation of latent virus.