The gene expression of ACSL4, BCL2, GOT1, NCOA4, NFS1, SLC11A2, SLC7A11, TF, and ZEB1 was positively associated with the OS of glioma patients, while the expression of AIFM2, ATF4, BECN1, FTH1, FTL, GPX4, HSPB1, KIAA1429, NFE2L2, SLC1A5, SLC40A1, TFRC, and TP53 were negatively correlated with OS. This evidence concerns the gene GPX4 and central nervous system cancer.