The gene expression of ACSL4, BCL2, GOT1, NCOA4, NFS1, SLC11A2, SLC7A11, TF, and ZEB1 was positively associated with the OS of glioma patients, while the expression of AIFM2, ATF4, BECN1, FTH1, FTL, GPX4, HSPB1, KIAA1429, NFE2L2, SLC1A5, SLC40A1, TFRC, and TP53 were negatively correlated with OS. Here, ACSL4 is linked to central nervous system cancer.