Furthermore, it has also been reported that immunotherapy-activated CD8+ T cells could induce cancer cell ferroptosis by decreasing SLC7A11 transcriptional expression and downstream secretion of IFN-γ, and consequently enhance the binding of signal transducer and activator of transcription 1 (STAT1) to the SLC7A11 transcription start site [21]. Here, STAT1 is linked to cancer.