Furthermore, GSEA revealed that gene hallmarks, including allograft rejection (NES = 1.812, normalized P=0.007), IL2-STAT5 signaling (NES = 1.792, normalized P=0.002), hypoxia (NES = 1.76, normalized P=0.019), glycolysis (NES = 1.844, normalized P=0.003), DNA repair (NES = 1.754, normalized P=0.043), complement (NES = 1.749, normalized P=0.012), coagulation (NES = 1.843, normalized P<0.001), and apoptosis (NES = 1.928, normalized P=0.002), were significantly associated with high-risk glioma patients (Figure 5D). Here, IL2 is linked to central nervous system cancer.