Therefore, to identify a potential upstream regulator miRNA of E2F1 in glioblastoma, we intersected the significantly downregulated miRNAs from the GSE103229 data series (screening criteria: P < 0.05 and logFC≤-2) and the predicted miRNAs that could regulate E2F1 by TargetScan algorithm. Here, E2F1 is linked to glioblastoma.