It is known that a number of cancer cell lines are highly autophagy‐dependent, and although they are generally resistant to loss of autophagic function (e.g. through ATG7 deletion), there is evidence that populations of cells are able to adapt to autophagy inhibition by upregulating different cellular pathways including NRF2 signalling (Towers et al, 2019). The gene discussed is NFE2L2; the disease is cancer.