TP53 and neoplasm: However, autophagy inhibition drives the accumulation of pre‐malignant pancreatic lesions in mice harbouring an activated oncogenic Kras allele upon p53 inactivation (Rosenfeldt et al, 2013), whereas p53 deletion‐driven tumour formation (in the absence of Kras activation) is protected against by autophagy inhibition (Yang et al, 2020).