In addition, a recent study including only cognitively unimpaired (CU) individuals demonstrated that the abnormal increase in different p‐tau species such as p‐tau217 or p‐tau231 occurred early within preclinical AD, when only minor changes in Aβ pathology can be detected in CSF (Suarez‐Calvet et al, 2020). This evidence concerns the gene MAPT and Alzheimer disease.