Because both VDR and p53 are known to regulate autophagic activity (Jin, 2005; Sun, 2016; Wu & Sun, 2011) and the impaired autophagy flux is functionally linked to amyloid deposition and gliosis, we wanted to know whether the VDR/p53 complex might contribute to the impaired autophagic flux in AD. Here, TP53 is linked to Alzheimer disease.