We performed an RNAi knockdown study of p53 and VDR in SH‐SY5Y cells and discovered that knocking down either p53 or VDR could reverse the autophagy and apoptosis caused by Aβ42 treatment alone or in combination with vitamin D3 (Figure S7), suggesting that the VDR/p53 interaction played an important role in mediating the Aβ‐induced autophagic neurodegeneration in AD. The gene discussed is TP53; the disease is Alzheimer disease.