Interestingly, several of these molecules, such as PAI‐1, IL‐6, or TGF‐β, have been shown to play a role in the development of glomerular lesions in several experimental models of CKD (Ding et al, 2001; Eddy & Fogo, 2006; Mei & Zheng, 2009). This evidence concerns the gene SERPINE1 and chronic kidney disease.