Since a number of previous studies showed that the increase in PAI‐1 expression is associated with the development of glomerular lesions in several experimental models of glomerular diseases (Rondeau et al, 1990; Yamamoto et al, 1993; Grandaliano et al, 2000; Lee et al, 2001; Hamano et al, 2002; Paueksakon et al, 2002), we decided to first focus on this paracrine mediator. Here, SERPINE1 is linked to glomerular disorder.