Activation of peripheral T cells in AD patients is elevated compared to healthy controls, and these T cells further promote peripheral blood mononuclear cells (PBMCs) to release proinflammatory factors including IL‐6, tumor necrosis factor α (TNFα), and IL‐1, all of which are essential immune modulators in AD pathology (Mietelska‐Porowska & Wojda, 2017; Tan et al., 2002). Here, IL1B is linked to Alzheimer disease.