Furthermore, analyses of peripheral blood from AD patients have shown that the number of IL‐2R+, HLA‐DR+, CD25+, and CD28+T cells was significantly higher than controls (Ikeda et al., 1991; Lombardi et al., 1999; Speciale et al., 2007), indicating an immune response in the peripheral system. The gene discussed is IL2RA; the disease is Alzheimer disease.