MAPT and Alzheimer disease: Neuropathologically, AD is remarkably characterized by two proteinaceous aggregate hallmarks, including tau‐hyperphosphorylation‐induced intracellular neurofibrillary tangles (NFTs) and extracellular depositions of amyloid plaques induced by beta‐amyloid peptide (Aβ) (Ittner & Gotz, 2011), which both contribute to synaptic damage and neuronal loss.