While phosphorylation is a common post‐translational modification of tau (Cleveland et al., 1977; Ksiezak‐Reding et al., 2003; Sengupta et al., 1998), abnormal hyperphosphorylation of tau leads to NFT formation and is neurotoxic in neurodegenerative diseases, including AD (Kenessey et al., 1995; Kopke et al., 1993; Ksiezak‐Reding et al., 1992). The gene discussed is MAPT; the disease is Alzheimer disease.