It is reported that gastric cancer‐derived exosomes can transfer various biological molecules to induce MMT of HMrSV5 cells, such as FasL, MMP2, nicotinamide N‐methyltransferase (NNMT), tripartite motif‐containing protein 3 (TRIM3), miR‐106 and miR‐21‐5p, which could regulate biological characteristics of HMrSV5 cells, thus facilitating metastasis of gastric cancer cells.44, 45, 46, 47, 48. This evidence concerns the gene MMP2 and gastric cancer.