We further confirmed that exosomal ANXA2 derived from ovarian cancer can promote the migration, invasion and apoptosis of HMrSV5 cells, indicating that ovarian cancer cells can transfer their tumour characteristics to HMrSV5 cells through exosomal ANXA2, and further to form a pre‐metastasis microenvironment suitable for ovarian cancer cell adhesion and colonization. This evidence concerns the gene ANXA2 and neoplasm.