To better understand the potential role of LRRC8A in vascular remodeling during hypertension, we next knocked in a construct containing a CAG promoter followed by a loxP‐Stop‐loxP‐LRRC8A coding region cassette, and we generated smooth muscle‐specific LRRC8A overexpression mice (LRRC8ASOE) by crossing this knock‐in mouse line with Tagln Cre mice (Figure S5). The gene discussed is LRRC8A; the disease is Hypertension.