During the challenge of hypertension, the activated LRRC8A channel‐mediated‐Cl− efflux increases WNK1 phosphorylation, which in turn triggers AKT phosphorylation and promotes BASMCs proliferation, eventually exacerbates hypertension‐induced cerebrovascular vascular remodeling. The gene discussed is LRRC8A; the disease is Hypertension.