Altogether, results in this present study demonstrate that LRRC8A is an essential component of VRAC, LRRC8A mediates cerebrovascular cell proliferation through WNK1/PI3K‐AKT signaling pathway and plays an important role in hypertension‐induced cerebrovascular remodeling, suggesting that LRRC8A is a potential therapeutic target for vascular remodeling. This evidence concerns the gene WNK1 and hypertensive disorder.