Their inflammation levels, including CRP, interleukin-6 (IL-6), and erythrocyte sedimentation rate (ESR), were measured using questionnaires to assess the activity of RA such as the Health Assessment Questionnaire (HAQ), visual analogue scale (VAS), and Disease Activity Score (DAS) 28; liver and kidney functions were compared between two groups. The gene discussed is IL6; the disease is rheumatoid arthritis.