In a phase one clinical trial from Baylor College of Medicine (NCT00902044) of 19 patients (median age = 14) with advanced HER2-CD28+ sarcomas, the administration of lymphodepletion (LD) chemotherapy was given to decrease the number of current T-cells and allowing room for new CAR-T cells, followed by autologous HER2-CAR-T cells, which was safely tolerated, providing SD in 3/16 OS patients past 12 weeks of therapy [51]. This evidence concerns the gene ERBB2 and sarcoma.