BRCA2 and breast carcinoma: Several risk factors have been associated with an increased chance of developing MBC, such as older age (≥70 years), family history of breast cancer in the first-degree relative, and hereditary genetic mutations (BRCA2 more commonly than BRCA1) [7,8]. Other risk factors include (a) Klinefelter syndrome, a congenital genetic abnormality resulting in a 47XXY genotype causing small testicles, lower levels of androgen hormones, and increased estrogen hormones, (b) use of exogenous estrogen, previously used as a treatment for prostate cancer, (c) obesity, and (d) history of chest radiation [8].