RUNX1 and Myocardial fibrosis: As expected, the stimulation of Runx1 in MI rats failed to rescue myocardial fibrosis as measured by the expression of fibrotic and apoptotic genes (Figures 6(f) and 6(g)) and was unable to mitigate cardiomyocyte hypertrophy even after dihydrolycorine treatment (Figure 6(h)).