Moreover, fibrotic genes such as collagen I, TGFβ, and p-smad3 and the apoptosis gene Bax were downregulated in the left ventricles of dihydrolycorine-treated MI rats (Figures 3(c) and 3(d)), thus preventing cardiomyocytes from becoming hypertrophic (Figure 3(a)) and irregular myocardial fibers and obscure intercellular borders in infarct areas (Figure 3(b)). Here, SMAD3 is linked to myocardial infarction.