Moreover, the protein expression of ALDH2 and SIRT1 in the T1DM group was significantly decreased compared with both the CON and T2DM groups indicated by immunofluorescence and Western blotting detections (all p < 0.05) (Figures 4(a) and 4(d)–4(f)). The gene discussed is SIRT1; the disease is type 1 diabetes mellitus.