In short, XNJY decoction, a TCM complex, could reduce neuronal damage; improve depression-like behavior in rats; inhibit the activation of NF-κB/IκB-α pathway; downregulate IL-6, TNF-α, and IL-1β inflammatory cytokine levels; restore IL-4, IL-10, and BDNF levels; and improve synaptic plasticity-related proteins including PSD-95 and SYN. Here, DLG4 is linked to major depressive disorder.