However, constitutive active PIK3CA (H1047R) overexpression did not show reduced pYAP and expression of YAP/TAZ regulated molecules, nor potentiated EGF-induced effects on this pathway and CTGF/CYR61 expression in HNSCC cells (Fig. 1f). The gene discussed is PIK3CA; the disease is head and neck squamous cell carcinoma.