SAV1 and hepatocellular carcinoma: Several reports have shown that PDK1 can form complex with the Hippo components including MST1/2, SAV1, LATS1/2, and PDK1 recruited to the plasma membrane triggered by PI3K leads to dissociation of these complex and YAP activation in MCF-10A, HEK293T, and hepatocellular carcinoma cells15,16.