In addition, when HNSCC patients from TCGA were stratified based on mRNA expression of EGFR, CTGF, and CYR61 (all z-score > 0 vs all z-score < 0), the EGFR, CTGF, and CYR61 “high” group (co-overexpression of EGFR and representative YAP-target genes) showed poorer survival with respect to those patients expressing low levels (high group: n = 128, low group: n = 114, Log-rank P = 0.015, Genhan-Breslow–Wilcoxon P = 0.0075). This evidence concerns the gene CCN2 and head and neck squamous cell carcinoma.