They had substantially higher levels of the analyzed modifications in their urine (except 8-oxodG) than the ETV6/RUNX1-negative ALL patients did, and the differences were significant for 5-hmdC, 5-hmCyt, 5-fCyt and 5-hmUra (Table S3 in Supplementary Materials). Here, RUNX1 is linked to acute lymphoblastic leukemia.