Concerning the allele-specific effect in mRNA expression (Fig. 2B), we observed opposite trends in the genotypes in controls and patients: while the minor-allele homozygotes showed a trend to have a lower NDFIP1 expression in MS patients compared to controls, the major allele carriers had a higher expression in MS patients than in controls, a difference that was statistically significant (p = 0.001). The gene discussed is NDFIP1; the disease is myeloid sarcoma.