Concordantly, phosphorylation of ERK (pERK) in SHP2i-sensitive codon 12-mutant PDAC and NSCLC, but not in Q61H-harboring resistant cells, was attenuated upon treatment with SHP2 inhibitors (Fig. 1d and Supplementary Fig. 1d). Here, PTPN11 is linked to non-small cell lung carcinoma.