Among these is tau, an intrinsically disordered protein (IDP) associated with microtubule (MT) stabilization3–5, whose deposition is implicated in multiple neurodegenerative tauopathies, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and Alzheimer’s disease (AD)6. This evidence concerns the gene MAPT and Alzheimer disease.