Thus, knockout TRPV6–/– mice exhibit defective intestinal Ca2+ absorption, increased urinary Ca2+ excretion, decreased femoral bone mineral density, lower body weight, alopecia, dermatitis, and severely impaired male fertility15–19, whereas changes in TRPV6 expression have been shown in several mouse models of human diseases20–24. Here, TRPV6 is linked to dermatitis.