Today, numerous mutations of the RyR2, defined as ryanopathies, are related to some arrhythmogenic disorders including CPVT, arrhythmogenic right ventricular cardiomyopathies (ARVC) under stress conditions or short-coupled polymorphic ventricular tachycardia (VT) when at rest- [7–10]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.