RYR2 and catecholaminergic polymorphic ventricular tachycardia: The so-called store-overload-induced calcium release (SOICR) hypothesis suggests that the CPVT-linked RyR2 mutations increase both, the sensitivity of the channel to luminal calcium and SOICR activity resulting in SR Ca2+ leak, DADs and arrhythmias, without affecting the affinity of the channel to FKBP12.6 [39].