In fifty percent of cases, the ARVD is caused by some autosomal dominant mutation in gene encoding desmosomal proteins like desmoplakin (DSP), plakoglobin (JUP), plakophilin-2 (PKP2), desmoglein-2 (DSG2) and desmocollin-2 (DSC2) [57]. The gene discussed is DSG2; the disease is arrhythmogenic right ventricular cardiomyopathy.