RYR1 and catecholaminergic polymorphic ventricular tachycardia: Thanks to the available 3D RyR1 and 2 structures, we now know that the majority of the RyR2 related CPVT mutations are located in domains involved in channel activation and gating including the pore, pseudo-voltage sensor and central domains (Fig. 1) [1, 34, 35].