NPPB and neuroblastoma: In order to assess whether BNP and CNP treatments affected the Wnt/β-catenin signaling as previously demonstrated for ANP [55], the neuroblastoma SHSY5Y cells, used as a model of DA neurons [55], were treated with the two NPs and the effects on β-catenin intracellular distribution and degradation were then analyzed after 6 and 24 h and compared with those of ANP, used as a positive control of efficacy (Fig. 1B–D).